SLC22A18（solute carrier family 22 member 18），癌症关联基因，基因ID：5002，该基因是位于11p15.5（一个重要的抑癌基因区）印记基因区的几种抑癌亚转移片段之一该区域的改变与Beckwith-Wiedemann综合征、肾母细胞瘤、横纹肌肉瘤、肾上腺皮质癌、肺癌、卵巢癌和乳腺癌有关。这个基因是印记，具有来自母体等位基因的优先表达。在肾母细胞瘤和肺癌中发现了这种基因的突变。该蛋白可能作为有机阳离子的转运体，在肾内氯喹和奎尼丁相关化合物的转运中起作用。已经描述了几种编码不同亚型的选择性剪接转录变体。[由RefSeq提供，2015年10月]This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5， an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome， Wilms tumor， rhabdomyosarcoma， adrenocortical carcinoma， and lung， ovarian， and breast cancer. This gene is imprinted， with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations， and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alt。