RPS6KA4（ribosomal protein S6 kinase A4），癌症关联基因，基因ID：8986，该基因编码丝氨酸/苏氨酸激酶rsk（核糖体s6激酶）家族的一个成员。该激酶包含2个不同的激酶催化结构域并磷酸化各种底物，包括creb1和atf1。编码的蛋白质还可以磷酸化组蛋白h3来调节某些炎症基因。已经发现了一些编码不同亚型的转录变体。[由RefSeq提供，2016年1月]This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates， including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jan 2016]。