RPL22(ribosomal protein L22),癌症关联基因,基因ID:6146,核糖体是催化蛋白质合成的细胞器,由一个小的40s亚基和一个大的60s亚基组成。这些亚基由4种RNA和大约80种结构上不同的蛋白质组成。这个基因编码一种细胞质核糖体蛋白,它是60S亚单位的一个组成部分该蛋白属于核糖体蛋白L22E家族其起始的蛋氨酸残基在翻译后被去除。该蛋白能与EBERs(EBERs)1和2特异性结合小鼠蛋白已被证明能与肝素结合。存在利用替代波利亚信号的转录变体。作为编码核糖体蛋白的典型基因,有多个经过处理的假基因散布在基因组中。先前认为该基因定位于3q26,在一些有3;21易位的治疗相关骨髓增生异常综合征患者中,它与位于21q22的急性髓系白血病1(AML1)基因融合;然而,这些融合实际上涉及位于3q26的核糖体蛋白L22假基因这个基因实际上定位于1p36.3-p36.2。[由RefSeq提供,2008年7月]Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse。