ROBO2（roundabout guidance receptor 2），癌症关联基因，基因ID：6092，这个基因编码的蛋白质属于ROBO家族，是从苍蝇到人类高度保守的免疫球蛋白超家族的一部分编码蛋白是slit同源蛋白2的跨膜受体，在轴突引导和细胞迁移中发挥作用该基因突变与膀胱输尿管反流有关，其特征是尿液从膀胱回流到输尿管或肾脏。选择性剪接导致多个转录变体[由RefSeq提供，2014年2月]The protein encoded by this gene belongs to the ROBO family， part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux， characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq， Feb 2014]。