REV1（REV1 DNA directed polymerase），癌症关联基因，基因ID：51455，该基因编码一种与酿酒酵母突变蛋白rev1相似的蛋白质。Rev1蛋白包含一个BRCT结构域，在蛋白质-蛋白质相互作用中起重要作用人类Rev1样蛋白的一个建议作用是作为一种支架，招募DNA聚合酶参与受损DNA的转运合成（TLS）[由RefSeq提供，2016年3月]This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain， which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq， Mar 2016]。