PRRX1（paired related homeobox 1），癌症关联基因，基因ID：5396，由该基因编码的dna相关蛋白是定位于细胞核的同源盒蛋白成对家族的成员。该蛋白作为转录辅激活剂，增强血清应答因子（生长和分化因子诱导基因所需的蛋白质）的dna结合活性。该蛋白调节肌肉肌酸激酶，表明在建立不同的中胚层肌肉类型的作用。选择性剪接产生两种在丰度和表达模式上不同的亚型。[由RefSeq提供，2008年7月]The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator， enhancing the DNA-binding activity of serum response factor， a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase， indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq， Jul 2008]。