PKD2（polycystin 2， transient receptor potential cation channel），癌症关联基因，基因ID：5311，这个基因编码多囊蛋白家族的一个成员。编码蛋白是一种多程膜蛋白，具有钙离子通道的功能，参与肾上皮细胞钙离子转运和钙信号转导该蛋白与多囊蛋白1相互作用，它们可能是参与肾小管形态发生的共同信号级联的伙伴。该基因突变与常染色体显性遗传多囊肾病2型相关[由RefSeq提供，2011年3月]This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel， and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1， and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq， Mar 2011]。