PER1（period circadian regulator 1），癌症关联基因，基因ID：5187，该基因是周期基因家族的一员，在哺乳动物大脑的主要昼夜节律起搏器视交叉上核以昼夜节律模式表达。这个家族的基因编码运动活动、新陈代谢和行为的昼夜节律这种基因被时钟/arntl异质二聚体上调，但随后在反馈回路中利用per/cry异质二聚体抑制这种上调，以与时钟/arntl相互作用。这种基因的多态性可能增加患某些癌症的风险在这个基因中已经观察到选择性剪接；然而，这些变异还没有被完全描述。[由RefSeq提供，2014年1月]This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus， the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity， metabolism， and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however， these variants have not been fully described. [provided by RefSeq， Jan 2014]。