PCLO（piccolo presynaptic cytomatrix protein），癌症关联基因，基因ID：27445，这个基因编码的蛋白质是突触前细胞骨架基质的一部分，它参与建立活跃的突触区和突触小泡的运输该基因的变异与双相情感障碍和重度抑郁障碍有关已经发现了两个编码不同亚型的转录变体。[由RefSeq提供，2011年11月]The protein encoded by this gene is part of the presynaptic cytoskeletal matrix， which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Nov 2011]。