OBSCN（obscurin， cytoskeletal calmodulin and titin-interacting RhoGEF），癌症关联基因，基因ID：84033，蒙脱石基因跨越150 kb以上，含有超过80个外显子，编码约720 kDa的蛋白质。编码蛋白包含68个ig结构域、2个纤维连接蛋白结构域、1个钙/钙调素结合结构域、1个rhogef结构域和2个丝氨酸苏氨酸激酶结构域。该蛋白属于包括Titin和Nebulin在内的巨大骶节信号蛋白家族，可能在肌原纤维的组装过程中起作用，并可能介导肌浆网和肌原纤维之间的相互作用。另外，还发现了编码不同亚型的剪接转录变体。[由RefSeq提供，2008年7月]The obscurin gene spans more than 150 kb， contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains， 2 fibronectin domains， 1 calcium/calmodulin-binding domain， 1 RhoGEF domain with an associated PH domain， and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin， and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been id。