NDRG1（N-myc downstream regulated 1），癌症关联基因，基因ID：10397，该基因属于N-myc下调基因家族，属于α/β水解酶超家族该基因编码的蛋白质是一种细胞质蛋白，参与应激反应、激素反应、细胞生长和分化。编码蛋白是p53介导的caspase活化和凋亡的必要条件该基因突变是4d型腓骨肌萎缩症的病因之一，该基因的表达可能是多种癌症的预后指标。另外，已经观察到该基因编码多个亚型的剪接转录变体[由RefSeq提供，2012年5月]This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses， hormone responses， cell growth， and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D， and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq， May 2012]。