MMP12（matrix metallopeptidase 12），癌症关联基因，基因ID：4321，该基因编码基质金属蛋白酶（mmps）的肽酶m10家族的一个成员。这个家族中的蛋白质参与正常生理过程中细胞外基质的分解，如胚胎发育、生殖和组织重塑，以及疾病过程，如关节炎和转移。编码的前蛋白经蛋白质水解处理产生成熟蛋白酶。这种蛋白酶降解可溶性和不溶性弹性蛋白。该基因可能参与了动脉瘤的形成，其突变与肺功能和慢性阻塞性肺疾病（copd）有关。这个基因是11号染色体上mmp基因簇的一部分。[由RefSeq提供，2016年1月]This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes， such as embryonic development， reproduction， and tissue remodeling， as well as in disease processes， such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on。