HLF(HLF transcription factor, PAR bZIP family member),癌症关联基因,基因ID:3131,该基因编码脯氨酸和富含酸性(PAR)蛋白家族的成员,BZIP转录因子的一个子集。编码的蛋白质与其他PAR家族成员形成同源二聚体或异源二聚体,并结合序列特异性启动子元件以激活转录。染色体易位将该基因的一部分与e2a基因融合,导致儿童b系急性淋巴细胞白血病的一个子集。已经描述了选择性剪接的转录变体,但其生物学有效性尚未确定。[由RefSeq提供,2008年7月]This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]。