G3BP1（G3BP stress granule assembly factor 1），癌症关联基因，基因ID：10146，该基因编码一种DNA解缠酶，该酶偏好部分解缠的3’-尾底物，也能以ATP依赖的方式解缠部分RNA/DNA和RNA/RNA双工这种酶是异质核RNA结合蛋白的一个成员，也是Ras信号转导途径的一个组成部分它通过与SH3结构域结合，特异性地与Ras GTPase激活蛋白结合已经描述了该基因的几个选择性剪接的转录变体，但其中一些变体的全长性质尚未确定。[由RefSeq提供，2008年7月]This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described， but the full-length nature of some of these variants has not been determined. [provided by RefSeq， Jul 2008]。