CDC27（cell division cycle 27），癌症关联基因，基因ID：996，该基因编码的蛋白与酿酒酵母Cdc27蛋白和pombe-nuc 2裂殖酵母的基因产物具有很强的相似性该蛋白是由8个蛋白亚基组成的后期促进复合物（APC）的组成部分，在真核细胞中高度保守该复合物催化细胞周期蛋白b泛素结合物的形成，该结合物负责泛素介导的b型细胞周期蛋白的蛋白水解。由该基因和apc复合物的其他三个成员编码的蛋白质含有四肽（tpr）重复序列，这对蛋白质-蛋白质相互作用很重要。该蛋白与Mad2、p55CDC和BUBR1等有丝分裂检查点蛋白相互作用，可能参与有丝分裂时间的调控该基因的选择性剪接导致多个转录变体。相关假基因已在第2、22和Y染色体上鉴定。[由RefSeq提供，2014年5月]The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27， and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC)， which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate， which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats， which are important。