AKAP8（A-kinase anchoring protein 8），癌症关联基因，基因ID：10270，这个基因编码a激酶锚蛋白家族的一个成员。a激酶锚定蛋白是含有蛋白激酶a（pka）的ri/rii亚单位的结合域并将pka和其他信号分子募集到特定亚细胞位置的支架蛋白。该基因编码一个核a激酶锚定蛋白，该蛋白与pka的riiα亚单位结合，并可能通过将pka和condensin复合物靶向染色质在有丝分裂过程中参与染色体凝聚。该基因的一个假基因位于9号染色体的短臂上。[由RefSeq提供，2011年5月]This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq， May 2011]。