ZNF148（zinc finger protein 148），癌症关联基因，基因ID：7707，该基因编码的蛋白是锌指dna结合蛋白kruppel家族的成员。编码的蛋白质激活T细胞受体和肠碱性磷酸酶基因的转录，但抑制鸟氨酸脱羧酶、波形蛋白、胃泌素、斯托梅林素和烯醇化酶基因的转录。该基因表达增加导致结直肠癌患者生存率降低，而该基因突变与整体发育迟缓、胼胝体发育不全和畸形相有关。[由RefSeq提供，2017年2月]The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase， vimentin， gastrin， stomelysin， and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer， while mutations in this gene have been associated with global developmental delay， hypoplastic corpus callosum， and dysmorphic facies. [provided by RefSeq， Feb 2017]。