XIAP（X-linked inhibitor of apoptosis），癌症关联基因，基因ID：331，该基因编码一种属于凋亡抑制蛋白家族的蛋白质。这个家族的成员有一个保守的基序，叫做杆状病毒iap重复序列，这对他们的抗凋亡功能是必要的。该蛋白通过与肿瘤坏死因子受体相关因子traf1和traf2结合发挥作用，并抑制自由基诱导剂甲萘醌和白细胞介素1β转化酶诱导的细胞凋亡。这种蛋白质还抑制至少两种细胞死亡蛋白酶caspase家族成员caspase-3和caspase-7。该基因突变是x连锁淋巴增生综合征的病因。交替剪接导致多个转录变体。该基因的假基因存在于2号和11号染色体上。[由RefSeq提供，2011年2月]This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed， baculovirus IAP repeat， which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione， a potent inducer of free radicals， and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases， caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative。