ZFHX3（zinc finger homeobox 3），癌症关联基因，基因ID：463，该基因编码一个具有多个同源结构域和锌指基序的转录因子，并调节肌源性和神经元分化。编码的蛋白质通过与富含at的增强子基序结合抑制甲胎蛋白基因的表达。该蛋白还被证明对c-myb具有负性调节作用，并反式激活细胞周期抑制剂细胞周期蛋白依赖性激酶抑制剂1a（也称为p21cip1）。据报道，该基因在几种癌症中起到抑癌作用，其序列变异也与心房颤动有关。从交替启动子表达并编码不同亚型的多个转录变体已经被发现。[由RefSeq提供，2009年9月]This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs， and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb， and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers， and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have bee。