WNT5A（Wnt family member 5A），癌症关联基因，基因ID：7474，wnt基因家族由编码分泌信号蛋白的结构相关基因组成。这些蛋白与肿瘤发生和一些发育过程有关，包括在胚胎发生过程中调节细胞命运和模式。该基因编码wnt家族的一个成员，该成员通过典型和非典型wnt途径发出信号。该蛋白是7个跨膜受体frizzled-5和酪氨酸激酶孤儿受体2的配体。这种蛋白质在胚胎发育过程中对发育途径起着重要的调节作用。这种蛋白也可能在肿瘤发生中起作用。该基因突变是常染色体显性遗传robinow综合征的病因。交替剪接导致多个转录变体。[由RefSeq提供，2012年1月]The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes， including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this ge。