TRAF5（TNF receptor associated factor 5），癌症关联基因，基因ID：7188，该基因编码的支架蛋白是肿瘤坏死因子受体相关因子（traf）蛋白家族的成员，包含meprin和traf同源性（math）结构域、一个环状锌指和两个traf型锌指。traf蛋白与肿瘤坏死因子受体超家族成员相关，并介导其信号转导。该蛋白是与肿瘤坏死因子（TNF）受体胞质结构域结合并介导TNF诱导活化的多蛋白复合物的组成部分之一。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2016年1月]The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain， a RING-type zinc finger， and two TRAF-type zinc fingers. TRAF proteins are associated with， and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jan 2016]。