SMARCE1（SWI/SNF related， matrix associated， actin dependent regulator of chromatin， subfamily e， member 1），癌症关联基因，基因ID：6605，该基因编码的蛋白质是大的atp依赖性染色质重塑复合物swi/snf的一部分，它是染色质正常抑制的基因转录激活所必需的。编码的蛋白质，单独或当在SWI/SNF复合物中，可以结合到4位连接DNA，这被认为在进入或退出核小体时模仿DNA的拓扑结构。该蛋白含有一个dna结合的hmg结构域，但该结构域的破坏并不能消除swi/snf复合物的dna结合或核小体置换活性。与大多数swi/snf复合蛋白不同，这种蛋白没有酵母对应物。[由RefSeq提供，2008年7月]The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF， which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein， either alone or when in the SWI/SNF complex， can bind to 4-way junction DNA， which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain， but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins， t。