NRP2(neuropilin 2),癌症关联基因,基因ID:8828,这个基因编码一个受体蛋白的神经肽家族成员。编码的跨膜蛋白与sema3c蛋白{sema结构域、免疫球蛋白结构域(ig)、短碱性结构域、分泌的(信号量)3c}和sema3f蛋白{sema结构域、免疫球蛋白结构域(ig)、短碱性结构域、分泌的(信号量)3f}结合,并与血管内皮生长因子(vegf)相互作用。这种蛋白可能在心血管发育、轴突引导和肿瘤发生中发挥作用。已鉴定出该基因编码不同亚型的多个转录变体。[由RefSeq提供,2008年7月]This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]。