MSH4（mutS homolog 4），癌症关联基因，基因ID：4438，这个基因编码一个dna错配修复muts家族的成员。该成员是一种减数分裂特异性蛋白质，不参与DNA错配纠正，但在减数分裂I时需要互惠重组和同源染色体的适当分离。该蛋白和msh5形成一个异二聚体，该异二聚体与Holliday连接点及其发育前体特异结合，从而激发adp-atp交换，稳定了减数分裂双链断裂修复过程中亲本染色体间的相互作用。[由RefSeq提供，2011年8月]This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction， but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor， thus provoking ADP-ATP exchange， and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq， Aug 2011]。