DPP6（dipeptidyl peptidase like 6），癌症关联基因，基因ID：1804，该基因编码一个单程ii型膜蛋白，它是丝氨酸蛋白酶肽酶s9b家族的成员。这种蛋白质没有可检测到的蛋白酶活性，很可能是由于缺乏丝氨酸蛋白酶催化域中通常存在的保守丝氨酸残基。然而，它确实结合了特定的电压门控钾通道，并改变了它们的表达和生物物理特性。该基因的变异可能与肌萎缩侧索硬化和特发性室颤的易感性有关。选择性剪接导致多个转录变体。[由RefSeq提供，2014年3月]This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity， most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However， it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq， Mar 2014]。