SPOP（speckle type BTB/POZ protein），癌症关联基因，基因ID：8405，该基因编码一种蛋白质，可调节死亡相关蛋白6（daxx）的转录抑制活性，daxx与组蛋白脱乙酰酶、核心组蛋白和其他组蛋白相关蛋白相互作用。在小鼠中，编码的蛋白质与macroh2a1.2的假定亮氨酸拉链结构域结合，macroh2a1.2是一种富含失活x染色体的变异h2a组蛋白。该蛋白的btb/poz结构域在其他蛋白质中被证明介导转录抑制并与组蛋白脱乙酰酶共抑制复合物的组分相互作用。该基因的选择性剪接导致编码相同蛋白质的多个转录变体。[由RefSeq提供，2008年7月]This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX)， which interacts with histone deacetylase， core histones， and other histone-associated proteins. In mouse， the encoded protein binds to the putative leucine zipper domain of macroH2A1.2， a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same prot。