AXIN1（axin 1），癌症关联基因，基因ID：8312，该基因编码一种细胞质蛋白，包含一个g蛋白信号（rgs）结构域和一个不规则的axin（dix）结构域。编码蛋白与大肠腺瘤性息肉病、连环蛋白β1、糖原合成酶激酶3β、蛋白磷酸2及自身相互作用。该蛋白作为无翅型mmtv整合位点家族成员1（wnt）信号通路的负调控因子，可诱导细胞凋亡。这种蛋白质的一部分的晶体结构，单独的和与其他蛋白质的复合物，已经被解决了。该基因突变与肝细胞癌、肝母细胞瘤、卵巢子宫内膜腺癌和髓质母细胞瘤有关。选择性剪接导致多个转录变体。[由RefSeq提供，2016年1月]This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli， catenin beta-1， glycogen synthase kinase 3 beta， protein phosphate 2， and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family， member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein， alone and in a complex with other proteins， has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma， hepatoblastomas， ovarian endometriod。