SOCS1（suppressor of cytokine signaling 1），癌症关联基因，基因ID：8651，该基因编码stat诱导的stat抑制因子（ssi）的一个成员，也被称为细胞因子信号传导抑制因子（socs）家族。ssi家族成员是细胞因子诱导的细胞因子信号负调控因子。该基因的表达可由一部分细胞因子诱导，包括il2、il3促红细胞生成素（epo）、csf2/gm-csf和ifn-γ。该基因编码的蛋白质在细胞因子受体下游发挥作用，并参与负反馈环以减弱细胞因子信号传导。小鼠的基因敲除研究表明该基因作为ifn-γ作用的调节因子，这是正常的产后生长和生存所必需的。[由RefSeq提供，2008年7月]This gene encodes a member of the STAT-induced STAT inhibitor (SSI)， also known as suppressor of cytokine signaling (SOCS)， family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines， including IL2， IL3 erythropoietin (EPO)， CSF2/GM-CSF， and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors， and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action， which is required for normal。