RNF43（ring finger protein 43），癌症关联基因，基因ID：54894，该基因编码的蛋白是一个环型e3泛素连接酶，预计包含跨膜结构域、蛋白酶相关结构域、外结构域和细胞质环结构域。这种蛋白被认为是负调节wnt信号的，这种基因的表达导致frizzled受体泛素化增加，亚细胞分布改变，导致这些受体的表面水平降低。在多个肿瘤细胞中，包括结直肠癌和子宫内膜癌中，这种基因的突变已经被报道。选择性剪接导致编码不同亚型的多个转录变体。[由RefSeq提供，2015年3月]The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain， a protease-associated domain， an ectodomain， and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling， and expression of this gene results in an increase in ubiquitination of frizzled receptors， an alteration in their subcellular distribution， resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells， including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq， Mar 2015]。