GRIN2A（glutamate ionotropic receptor NMDA type subunit 2A），癌症关联基因，基因ID：2903，这个基因编码谷氨酸门控离子通道蛋白家族的一个成员。编码蛋白是n-甲基-d-天冬氨酸（nmda）受体亚单位。nmda受体既依赖于配体门控，又依赖于电压，并参与长期增强，一种依赖于活动的突触传递效率的提高，被认为是某种记忆和学习的基础。这些受体对钙离子具有渗透性，其激活导致钙离子流入突触后细胞，从而激活多个信号级联。这种基因的破坏与局灶性癫痫和言语障碍有关，不论是否有认知障碍。选择性剪接导致多个转录变体。[由RefSeq提供，2014年5月]This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent， and are involved in long-term potentiation， an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions， and activation results in a calcium influx into post-synaptic cells， which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or w。