RSF1（remodeling and spacing factor 1），癌症关联基因，基因ID：51773，该基因编码一种与乙型肝炎病毒X蛋白（hbx）相互作用的核蛋白，并通过hbx转录激活剂促进乙型肝炎病毒基因的转录，提示这种相互作用在病毒生命周期中的作用。该蛋白也与snf2h蛋白相互作用，形成rsf染色质重塑复合物，其中snf2h亚单位作为核小体依赖性atpase，该蛋白作为组蛋白伴侣。This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator， suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex， where the SNF2H subunit functions as the nucleosome-dependent ATPase， and this protein as the histone chaperone.关联癌症：乳腺癌。