VPS37A（VPS37A， ESCRT-I subunit），癌症关联基因，基因ID：137492，该基因属于VPS37家族，编码ESCRT-I（运输I所需的内质分选复合物）蛋白复合物的一个组成部分，将泛素化跨膜蛋白分类到多泡体内。该基因在肝细胞癌中的表达下调，该基因的突变与常染色体隐性痉挛性截瘫-53有关。在5号染色体上发现了一个相关的假基因。另外，还发现了该基因的剪接转录变体。This gene belongs to the VPS37 family， and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex， required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma， and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.关联癌症：卵巢癌。关联化疗药物：西妥昔单抗。