SPHK1（sphingosine kinase 1），癌症关联基因，基因ID：8877，该基因编码的蛋白质催化鞘氨醇的磷酸化形成鞘氨醇-1-磷酸（S1P），一种具有细胞内和细胞外功能的脂质介质。在细胞内，s1p调节增殖和存活，在细胞外，它是细胞表面G蛋白偶联受体的配体。这种蛋白及其产物s1p在TNFα信号传导和在炎症、抗凋亡和免疫过程中重要的NF-kappa-b激活途径中起关键作用。另外，还发现了编码不同亚型的剪接转录变体。The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P)， a lipid mediator with both intra- and extracellular functions. Intracellularly， S1P regulates proliferation and survival， and extracellularly， it is a ligand for cell surface G protein-coupled receptors. This protein， and its product S1P， play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory， antiapoptotic， and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.关联癌症：宫颈癌。