KDM5C（lysine demethylase 5C），癌症关联基因，基因ID：8242，该基因是smcy同系物家族的成员，编码一个干旱区、一个jmjc区、一个jmjn区和两个phd型锌指蛋白。DNA结合基序表明该蛋白参与转录和染色质重塑的调节。这种基因的突变与X连锁精神发育迟滞有关。选择性剪接导致多个转录变体。This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain， one JmjC domain， one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants.关联癌症：肾细胞癌。关联化疗药物：依维莫司，舒尼替尼。