RPS6（ribosomal protein S6），癌症关联基因，基因ID：6194，核糖体是催化蛋白质合成的细胞器，由一个小的40S亚单位和一个大的60S亚单位组成。这些亚单位由4种RNA和大约80种结构不同的蛋白质组成。这个基因编码一种细胞质核糖体蛋白，它是40S亚单位的组成部分。该蛋白属于核糖体蛋白的S6E家族。是核糖体中蛋白激酶的主要底物，五个C端丝氨酸残基的亚群被不同的蛋白激酶磷酸化。磷酸化是由多种刺激物诱导的，包括生长因子、肿瘤促进剂和有丝分裂原。生长停滞时发生去磷酸化。该蛋白可通过选择性翻译特定类别的mRNA来帮助控制细胞的生长和增殖。与编码核糖体蛋白的基因一样，该基因有多个经过处理的假基因散布在基因组中。Ribosomes， the organelles that catalyze protein synthesis， consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome， with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli， including growth factors， tumor-promoting agents， a。