RHEB（Ras homolog enriched in brain），癌症关联基因，基因ID：6009，该基因是小GTP酶超家族的成员，编码一种脂质锚定的细胞膜蛋白，具有5个重复的ras相关GTP结合区。由于这种蛋白在胰岛素/Tor/S6K信号通路中的作用，它在调节生长和细胞周期进程中是至关重要的。蛋白质具有GTP酶活性，在GDP结合形式和GTP结合形式之间穿梭，这种活性需要蛋白质的法呢酰化。已经绘制了三个假基因，其中两个在10号染色体上，另一个在22号染色体上。This gene is a member of the small GTPase superfamily and encodes a lipid-anchored， cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form， and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped， two on chromosome 10 and one on chromosome 22.关联癌症：肾癌。关联化疗药物：替西罗莫司/坦西莫司。