RAC1（ras-related C3 botulinum toxin substrate 1 (rho family， small GTP binding protein Rac1)），癌症关联基因，基因ID：5879，该基因编码的蛋白是一种GTP酶，属于小GTP结合蛋白的ras超家族。这个超家族的成员似乎调节着各种各样的细胞事件，包括控制细胞生长、细胞骨架重组和蛋白激酶的激活。两个编码不同亚型的转录变体已经被发现。The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events， including the control of cell growth， cytoskeletal reorganization， and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.关联癌症：黑色素瘤。关联化疗药物：达拉非尼，维莫非尼，威罗菲尼。