PIM1（Pim-1 proto-oncogene， serine/threonine kinase），癌症关联基因，基因ID：5292，该基因编码的蛋白属于SER/THR蛋白激酶家族和PIM亚家族。该基因主要在B淋巴细胞和骨髓细胞系中表达，在造血恶性肿瘤和前列腺癌中过表达。在血细胞信号转导中起作用，有助于细胞增殖和存活，从而在肿瘤发生中提供选择性优势。据报道，人类和正常小鼠的基因都编码两种亚型（具有优先的细胞定位），这两种亚型是由于在帧翻译起始密码子中使用了替代的，即上游非aug（cug）和下游aug密码子（pmids:161868051825810）。The protein encoded by this gene belongs to the Ser/Thr protein kinase family， and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines， and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells， contributing to both cell proliferation and survival， and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons， the upstream non-AUG (CUG) and downstream AUG codons。