HMOX1（heme oxygenase 1），癌症关联基因，基因ID：3162，血红素加氧酶是血红素分解代谢中的一种重要酶，它将血红素分解成胆绿素，胆绿素还原酶和一氧化碳（一种公认的神经递质）随后将胆绿素转化为胆红素。血红素加氧酶活性是由底物血红素和各种非血红素物质诱导的。血红素加氧酶以2种同工酶、一种诱导性血红素加氧酶-1和一种组成性血红素加氧酶-2的形式存在。hmox1和hmox2属于血红素加氧酶家族。Heme oxygenase， an essential enzyme in heme catabolism， cleaves heme to form biliverdin， which is subsequently converted to bilirubin by biliverdin reductase， and carbon monoxide， a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes， an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.关联癌症：肾细胞癌。关联化疗药物：索拉非尼，舒尼替尼。