SIRT1（sirtuin 1），癌症关联基因，基因ID：23411，这个基因编码sirtuin蛋白家族的一个成员，与酵母sir2蛋白同源。sirtuin家族成员以sirtuin核心域为特征，分为四类。人类sirtuin的功能尚未确定；然而，已知酵母sirtuin蛋白可调节表观遗传基因沉默和抑制RDNA的重组。研究表明，人sirtuins可能作为具有单ADP核糖转移酶活性的细胞内调节蛋白发挥作用。该基因编码的蛋白质包含在sirtuin家族的I类中。选择性剪接导致多个转录变体。This gene encodes a member of the sirtuin family of proteins， homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however， yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.关联癌症：胰腺癌。