PTPRD（protein tyrosine phosphatase， receptor type D），癌症关联基因，基因ID：5789，该基因编码的蛋白是蛋白酪氨酸磷酸酶（PTP）家族的成员。众所周知，PTP是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP包含一个细胞外区、一个单跨膜段和两个串联胞质内催化域，因此代表一种受体型PTP。该蛋白的细胞外区由三个免疫球蛋白样结构域和八个纤维连接蛋白III型结构域组成。对鸡和苍蝇的相似基因的研究表明，这种PTP在促进轴突生长和调节神经元轴突引导中的作用。该基因的多种选择性剪接转录变体已被报道。在5号染色体上发现了一个相关的假基因。The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth， differentiation， mitotic cycle， and oncogenic transformation. This PTP contains an extracellular region， a single transmembrane segment and two tandem intracytoplasmic catalytic domains， and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting 。