TSC2（tuberous sclerosis 2），癌症关联基因，基因ID：7249，这个基因的突变导致结节性硬化症。其基因产物被认为是一种肿瘤抑制因子，能够刺激特定的GTP酶。这种蛋白在细胞溶质复合体中与哈马汀结合，可能作为哈马汀的伴侣。选择性剪接导致编码不同亚型的多个转录变体。Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex， possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.关联癌症：肾细胞癌，甲状腺癌，结节性硬化。关联化疗药物：依维莫司，MTOR Inhibitors。