MYC（v-myc avian myelocytomatosis viral oncogene homolog），癌症关联基因，基因ID：4609，该基因编码的蛋白质是一种多功能的核磷蛋白，在细胞周期进展、凋亡和细胞转化中起到作用。作为调节特定靶基因转录的转录因子发挥作用。这种基因的突变、过度表达、重排和易位与多种造血肿瘤、白血病和淋巴瘤，包括伯基特淋巴瘤有关。有证据表明，来自上游、非aug（cug）帧和下游aug起始位点的选择性翻译起始导致两种具有不同N末端的亚型的产生。在伯基特淋巴瘤中，非aug启动蛋白的合成受到抑制，这表明它在该基因正常功能中的重要性。The protein encoded by this gene is a multifunctional， nuclear phosphoprotein that plays a role in cell cycle progression， apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations， overexpression， rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors， leukemias and lymphomas， including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream， in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of no。