AKT3（AKT serine/threonine kinase 3），癌症关联基因，基因ID：10000，这个基因编码的蛋白质是AKT的一个成员，也被称为pkb，丝氨酸/苏氨酸蛋白激酶家族。Akt激酶是已知的细胞信号调节器，对胰岛素和生长因子作出反应。参与多种生物学过程，包括细胞增殖、分化、凋亡、肿瘤发生以及糖原合成和葡萄糖摄取。这种激酶被血小板衍生生长因子（pdgf）、胰岛素和胰岛素样生长因子1（igf1）刺激。另外，还描述了编码不同亚型的剪接转录变体。The protein encoded by this gene is a member of the AKT， also called PKB， serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation， differentiation， apoptosis， tumorigenesis， as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF)， insulin， and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.关联癌症：乳腺癌，黑色素瘤，三受体阴性乳腺癌。关联化疗药物：AKT3 Inhibitor，GSK690693，MK-2206 2HCl，维莫非尼，威罗菲尼。