PBRM1（polybromo 1），癌症关联基因，基因ID：55193，这个位点编码一个ATP依赖染色质重塑复合物的亚单位。编码蛋白被鉴定为核激素受体激活配体依赖性转录所必需的复合物的组成部分。该位点的突变与原发性透明细胞肾细胞癌有关。This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.关联癌症：透明细胞肾细胞癌，肾细胞癌。关联化疗药物：阿特珠单抗，阿替利珠单抗，阿维单抗，度伐利尤单抗，德瓦鲁单抗，CTLA-4 Inhibitor，依维莫司，伊匹单抗，伊匹木单抗 ，Y药，CTLA4单抗，PD-L1 Antibody，派姆单抗，帕博利珠单抗，纳武单抗，纳武利尤单抗。