SPRY4（sprouty RTK signaling antagonist 4），癌症关联基因，基因ID：81848，这个基因编码富含半胱氨酸和脯氨酸的蛋白质家族的一个成员。编码蛋白是受体介导的丝裂原活化蛋白激酶（MAPK）信号通路的抑制剂这种蛋白的活性损害了活性GTP-RAS的形成该基因的核苷酸变异与伴有或不伴有嗅觉缺失的促性腺激素减退症17有关。选择性剪接导致多个转录变体。[由RefSeq提供，2014年6月]This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq， Jun 2014]。