SMC3（structural maintenance of chromosomes 3），癌症关联基因，基因ID：9126，该基因属于SMC蛋白的SMC3亚家族。编码蛋白以细胞内蛋白、核蛋白或分泌蛋白的形式存在于某些细胞类型中。核的形态，被称为3号染色体的结构维持，是有丝分裂期间将姐妹染色单体结合在一起的多聚体黏着蛋白复合体的一个组成部分，能够实现染色体的正确分离。通过添加硫酸软骨素链对编码蛋白进行翻译后修饰，产生分泌的蛋白多糖bamacan，一种丰富的基底膜蛋白。[由RefSeq提供，2008年7月]This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular， nuclear protein or a secreted protein. The nuclear form， known as structural maintenance of chromosomes 3， is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis， enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan， an abundant basement membrane protein. [provided by RefSeq， Jul 2008]。