PRKCE（protein kinase C epsilon），癌症关联基因，基因ID：5581，蛋白激酶C（PKC）是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活pkc家族成员磷酸化多种蛋白质靶点，参与多种细胞信号传导途径。PKC家族成员也是一类肿瘤促进剂佛波酯的主要受体pkc家族的每个成员都有一个特定的表达谱，并被认为在细胞中发挥着独特的作用。该基因编码的蛋白是pkc家族成员之一。这种激酶参与了许多不同的细胞功能，如神经元通道激活、细胞凋亡、心肌缺血保护、热休克反应以及胰岛素分泌敲除小鼠的研究表明，这种激酶对于脂多糖（LPS）介导的激活巨噬细胞中的信号是重要的，并且还可能起到控制焦虑样行为的作用。[由RefSeq提供，2008年7月]Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters， a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved 。