MACF1（microtubule actin crosslinking factor 1），癌症关联基因，基因ID：23499，该基因编码一个含有大量光谱蛋白和富含亮氨酸重复序列（lrr）结构域的大蛋白。编码的蛋白质是一个蛋白质家族的成员，在不同的细胞骨架元素之间形成桥梁这种蛋白促进细胞周围肌动蛋白微管的相互作用，并将微管网络连接到细胞连接处。选择性剪接导致多个转录变体，但其中一些变体的全长性质尚未确定[由RefSeq提供，2013年5月]This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants， but the full-length nature of some of these variants has not been determined. [provided by RefSeq， May 2013]。