LRRFIP2（LRR binding FLII interacting protein 2），癌症关联基因，基因ID：9209，该基因编码的蛋白与myd88结合在toll样受体4（tlr4）的胞浆末端，从而激活核因子kappa b信号传导。泛素样蛋白fat10阻止编码蛋白与tlr4的相互作用，从而使核因子kappa b信号途径失活。此外，这种蛋白可以通过将caspase-1抑制剂flightless-i招募到炎症复合物中来下调nlrp3炎症。[由RefSeq提供，2017年1月]The protein encoded by this gene， along with MYD88， binds to the cytosolic tail of toll-like receptor 4 (TLR4)， which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4， thereby inactivating the nuclear factor kappa B signaling pathway. In addition， this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq， Jan 2017]。